Dipartimento di Biochimica e Biologia Molecolare E. Quagliariello, Università di Bari, Bari, Italy.
Mitochondrion. 2011 Mar;11(2):360-5. doi: 10.1016/j.mito.2010.10.005. Epub 2010 Nov 6.
RNA editing is a post-transcriptional molecular process whereby the information in a genetic message is modified from that in the corresponding DNA template by means of nucleotide substitutions, insertions and/or deletions. It occurs mostly in organelles by clade-specific diverse and unrelated biochemical mechanisms. RNA editing events have been annotated in primary databases as GenBank and at more sophisticated level in the specialized databases REDIdb, dbRES and EdRNA. At present, REDIdb is the only freely available database that focuses on the organellar RNA editing process and annotates each editing modification in its biological context. Here we present an updated and upgraded release of REDIdb with a web-interface refurbished with graphical and computational facilities that improve RNA editing investigations. Details of the REDIdb features and novelties are illustrated and compared to other RNA editing databases. REDIdb is freely queried at http://biologia.unical.it/py_script/REDIdb/.
RNA 编辑是一种转录后分子过程，通过核苷酸取代、插入和/或缺失，使遗传信息从相应的 DNA 模板中得到修改。它主要通过分支特异性的不同和不相关的生化机制在细胞器中发生。RNA 编辑事件已在主要数据库（如 GenBank）中注释，并在更复杂的专门数据库 REDIdb、dbRES 和 EdRNA 中进行注释。目前，REDIdb 是唯一专注于细胞器 RNA 编辑过程并在其生物学背景下注释每个编辑修饰的免费数据库。在这里，我们展示了一个经过更新和升级的 REDIdb 版本，其带有图形和计算功能的网页界面进行了翻新，这提高了 RNA 编辑研究的效率。详细说明了 REDIdb 的特点和新颖之处，并与其他 RNA 编辑数据库进行了比较。可以在 http://biologia.unical.it/py_script/REDIdb/ 免费查询 REDIdb。
