Zamani Farhad, Ameli Mitra, Razmjou Sara, Shakeri Ramin, Amiri Afsaneh, Darvish Rasoul
Gastrointestinal and Liver Disease Research Center, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Saudi J Kidney Dis Transpl. 2010 Nov;21(6):1169-71.
Hepatitis C virus (HCV) is one of the perilous problems in hemodialysis (HD) centers around the world. There are many risk factors regarding HCV infection in HD units. The aim of this study was to evaluate the incidence of HCV infection in HD units and also to assess the potential risk factors in this regard. A total of 334 patients on regular HD were evaluated. All the patients were seronegative for anti-HCV antibody in the beginning of this study. They were followed every 6 months with repetition of tests. Positive samples were tested by polymerase chain reaction (PCR) for confirmation. The prevalence of HCV infection was about 20%. No significant relationship between numbers of blood transfusion, age and sex was obtained. A positive correlation between HCV infection and duration of HD for more than 5 years was significant. In conclusion, our study found the prevalence of HCV infection to be significantly higher than its incidence in the general population.
丙型肝炎病毒（HCV）是全球血液透析（HD）中心面临的危险问题之一。血液透析单位存在许多与HCV感染相关的风险因素。本研究的目的是评估血液透析单位HCV感染的发生率，并评估这方面的潜在风险因素。共评估了334例接受常规血液透析的患者。在本研究开始时，所有患者的抗HCV抗体血清学检测均为阴性。每6个月对他们进行随访并重复检测。阳性样本通过聚合酶链反应（PCR）进行检测以确认。HCV感染的患病率约为20%。未发现输血次数、年龄和性别之间存在显著关系。HCV感染与血液透析持续时间超过5年之间存在显著正相关。总之，我们的研究发现HCV感染的患病率显著高于普通人群中的发病率。
