Cockerill P N, Klinken S P
Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.
Mol Cell Biol. 1990 Mar;10(3):1293-6. doi: 10.1128/mcb.10.3.1293-1296.1990.
The immunoglobulin genes have B-cell-specific promoter and enhancer elements. The regulation of these elements is thought to be mediated to a large degree by the trans-activating factor oct-2, which binds the octamer element (ATTTGCAT). We have further examined the role of this octamer element in directing the lymphoid-specific expression of the immunoglobulin H enhancer. No direct relationship was found between the levels of expression of the Cmu gene and oct-2. Indeed, variable amounts of oct-2 were detected in all of the hemopoietic lineage cells tested in this study.
免疫球蛋白基因具有B细胞特异性启动子和增强子元件。这些元件的调控在很大程度上被认为是由反式激活因子oct-2介导的，oct-2可与八聚体元件（ATTTGCAT）结合。我们进一步研究了该八聚体元件在指导免疫球蛋白H增强子的淋巴样特异性表达中的作用。未发现Cmu基因的表达水平与oct-2之间存在直接关系。事实上，在本研究检测的所有造血谱系细胞中均检测到了不同量的oct-2。
