Dengue Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico.
PLoS One. 2010 Oct 28;5(10):e13729. doi: 10.1371/journal.pone.0013729.
Periodic outbreaks of dengue fever occur in the United States Virgin Islands. In June 2005, an outbreak of dengue virus (DENV) serotype-2 with cases of dengue hemorrhagic fever (DHF) was detected in St. Croix, US Virgin Islands. The objective of this report is to describe this outbreak of DENV-2 and the findings of a case-control study examining risk factors for DHF.
METHODOLOGY/PRINCIPAL FINDINGS: This is the largest dengue outbreak ever recorded in St. Croix, with 331 suspected dengue cases reported island-wide during 2005 (62.2 cases/10,000 population); 54% were hospitalized, 21% had at least one hemorrhagic manifestation, 28% had thrombocytopenia, 5% had DHF and 1 patient died. Eighty-nine laboratory-positive hospitalized patients were identified. Of these, there were 15 (17%) who met the WHO criteria for DHF (cases) and 74 (83%) who did not (controls). The only variable significantly associated with DHF on bivariate or multivariable analysis was age, with an adjusted odds ratio (95% confidence interval) of 1.033 (1.003,1.064).
CONCLUSIONS/SIGNIFICANCE: During this outbreak of DENV-2, a high proportion of cases developed DHF and increasing age was significantly associated with DHF.
周期性爆发登革热在美国维尔京群岛发生。2005 年 6 月，在美国维尔京群岛圣克罗伊岛检测到登革热病毒（DENV）血清型-2 的爆发，伴有登革出血热（DHF）病例。本报告的目的是描述这次 DENV-2 爆发和对登革出血热危险因素进行病例对照研究的结果。
方法/主要发现：这是圣克罗伊岛有史以来最大的登革热爆发，2005 年全岛报告了 331 例疑似登革热病例（62.2 例/10000 人口）；54%住院，21%有至少一种出血表现，28%血小板减少，5%有 DHF，1 例死亡。确定了 89 例住院实验室阳性患者。其中，有 15 例（17%）符合世界卫生组织 DHF 标准（病例），74 例（83%）不符合（对照组）。在单变量或多变量分析中，唯一与 DHF 显著相关的变量是年龄，调整后的优势比（95%置信区间）为 1.033（1.003，1.064）。
结论/意义：在这次 DENV-2 爆发中，很大比例的病例发展为 DHF，年龄增长与 DHF 显著相关。
