AB血型与二次感染时严重登革热疾病风险增加有关。

Blood group AB is associated with increased risk for severe dengue disease in secondary infections.

作者信息

Kalayanarooj Siripen, Gibbons Robert V, Vaughn David, Green Sharone, Nisalak Ananda, Jarman Richard G, Mammen Mammen P, Perng Guey-Chuen

机构信息

Queen Sirikit National Institute of Child Health, US Army Medical Corps-Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

出版信息

J Infect Dis. 2007 Apr 1;195(7):1014-7. doi: 10.1086/512244. Epub 2007 Feb 23.

DOI:10.1086/512244

PMID:17330792

Abstract

Why certain individuals progress to severe dengue disease is unknown. In this study, blood groups associated with dengue disease were investigated. ABO phenotypes were identified by use of serum from 399 patients with dengue-virus infection who participated in a cohort study. ABO blood-group frequencies were similar in primary versus secondary dengue-virus infections. However, in secondary infection, individuals with blood group AB were likely to have dengue hemorrhagic fever grade 3 than either grades 1 and 2 combined (corrected P value, <.0001; odds ratio, 0.097 [95% confidence interval, 0.03-0.33]) or dengue fever (corrected P value, <.0001; odds ratio, 0.119 [95% confidence interval, 0.04-0.37]). To our knowledge, this is the first report demonstrating an association between ABO blood group and the severity of dengue disease.

摘要

为何某些个体的登革热病情会发展为重症尚不清楚。在本研究中，对与登革热疾病相关的血型进行了调查。通过使用参与一项队列研究的399例登革病毒感染患者的血清来确定ABO血型表型。在初次与二次登革病毒感染中，ABO血型频率相似。然而，在二次感染中，AB血型个体发生3级登革出血热的可能性高于1级和2级登革出血热的总和（校正P值，<.0001；比值比，0.097 [95%置信区间，0.03 - 0.33]）或登革热（校正P值，<.0001；比值比，0.119 [95%置信区间，0.04 - 0.37]）。据我们所知，这是首份证明ABO血型与登革热疾病严重程度之间存在关联的报告。