Department of Anaesthesiology, General Intensive Care, and Pain Control, Medical University of Vienna General Hospital, A-1090 Vienna, Austria.
BMJ. 2010 Nov 9;341:c5943. doi: 10.1136/bmj.c5943.
To determine which bedside method of detecting inadvertent endobronchial intubation in adults has the highest sensitivity and specificity.
Prospective randomised blinded study.
Department of anaesthesia in tertiary academic hospital.
160 consecutive patients (American Society of Anesthesiologists category I or II) aged 19-75 scheduled for elective gynaecological or urological surgery.
Patients were randomly assigned to eight study groups. In four groups, an endotracheal tube was fibreoptically positioned 2.5-4.0 cm above the carina, whereas in the other four groups the tube was positioned in the right mainstem bronchus. The four groups differed in the bedside test used to verify the position of the endotracheal tube. To determine whether the tube was properly positioned in the trachea, in each patient first year residents and experienced anaesthetists were randomly assigned to independently perform bilateral auscultation of the chest (auscultation); observation and palpation of symmetrical chest movements (observation); estimation of the position of the tube by the insertion depth (tube depth); or a combination of all three (all three).
Correct and incorrect judgments of endotracheal tube position.
160 patients underwent 320 observations by experienced and inexperienced anaesthetists. First year residents missed endobronchial intubation by auscultation in 55% of cases and performed significantly worse than experienced anaesthetists with this bedside test (odds ratio 10.0, 95% confidence interval 1.4 to 434). With a sensitivity of 88% (95% confidence interval 75% to 100%) and 100%, respectively, tube depth and the three tests combined were significantly more sensitive for detecting endobronchial intubation than auscultation (65%, 49% to 81%) or observation(43%, 25% to 60%) (P<0.001). The four tested methods had the same specificity for ruling out endobronchial intubation (that is, confirming correct tracheal intubation). The average correct tube insertion depth was 21 cm in women and 23 cm in men. By inserting the tube to these distances, however, the distal tip of the tube was less than 2.5 cm away from the carina (the recommended safety distance, to prevent inadvertent endobronchial intubation with changes in the position of the head in intubated patients) in 20% (24/118) of women and 18% (7/42) of men. Therefore optimal tube insertion depth was considered to be 20 cm in women and 22 cm in men.
Less experienced clinicians should rely more on tube insertion depth than on auscultation to detect inadvertent endobronchial intubation. But even experienced physicians will benefit from inserting tubes to 20-21 cm in women and 22-23 cm in men, especially when high ambient noise precludes accurate auscultation (such as in emergency situations or helicopter transport). The highest sensitivity and specificity for ruling out endobronchial intubation, however, is achieved by combining tube depth, auscultation of the lungs, and observation of symmetrical chest movements.
NCT01232166.
确定哪种床边方法检测成人意外支气管内插管具有最高的灵敏度和特异性。
前瞻性随机对照盲法研究。
三级学术医院麻醉科。
160 例连续患者(美国麻醉医师协会分类 I 或 II 级),年龄 19-75 岁,择期行妇科或泌尿科手术。
患者随机分为 8 个研究组。在 4 组中,纤维支气管镜将气管插管定位在隆突上方 2.5-4.0cm 处,而在另外 4 组中,将气管插管定位在右主支气管。这 4 组的床边检测方法不同,用于验证气管插管的位置。为了确定气管插管是否正确定位,在每个患者中,住院医师和经验丰富的麻醉师被随机分配,分别独立进行双侧胸部听诊(听诊);观察和触诊对称的胸部运动(观察);根据插入深度估计管的位置(管深度);或三者结合(三者)。
正确和不正确的气管插管位置判断。
160 例患者由经验丰富和缺乏经验的麻醉师进行了 320 次观察。住院医师在 55%的病例中通过听诊漏诊了支气管内插管,并且与该床边检查相比,表现明显差于经验丰富的麻醉师(比值比 10.0,95%置信区间 1.4 至 434)。管深度和三种检查联合检测的灵敏度分别为 88%(95%置信区间 75%至 100%)和 100%,显著高于听诊(65%,49%至 81%)或观察(43%,25%至 60%)(P<0.001)。四种测试方法对排除支气管内插管的特异性相同(即,确认正确的气管插管)。女性的平均正确插管深度为 21cm,男性为 23cm。然而,通过插入这些距离的管子,管子的远端尖端距离隆突(防止在插管患者头部位置改变时发生意外支气管内插管的推荐安全距离)不到 2.5cm,在 20%(24/118)的女性和 18%(7/42)的男性中。因此,建议女性的最佳插管深度为 20cm,男性为 22cm。
经验不足的临床医生应更多地依赖管插入深度而不是听诊来检测意外的支气管内插管。但即使是经验丰富的医生也将受益于将管子插入 20-21cm 的女性和 22-23cm 的男性,特别是在环境噪音过高而无法准确听诊(如在紧急情况下或直升机转运)时。然而,为了排除支气管内插管,管深度、肺部听诊和对称胸部运动的观察相结合,具有最高的灵敏度和特异性。
NCT01232166。