Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Occup Environ Med. 2010 Nov;52(11):1119-23. doi: 10.1097/JOM.0b013e3181f84577.
To evaluate methods for determining excessive short-term decline in forced expiratory volume in one second (FEV1) in diacetyl-exposed workers.
We evaluated five methods of determining excessive longitudinal FEV1 decline in diacetyl-exposed workers and workers from a comparative cohort: American Thoracic Society (ATS), ACOEM an 8% limit, and a relative and absolute longitudinal limit on the basis of spirometry data variability. Relative risk and incidence of excess decline were evaluated.
Incidence of excessive FEV1 decline was 1% in the comparative cohort using ATS and ACOEM criteria, 4.1% using relative limit of longitudinal decline, 4.4% with absolute longitudinal limit of decline, and 5.6% by using the 8% limit. Relative risk of abnormal FEV1 decline in diacetyl-exposed workers was elevated in all evaluated methods.
Alternative methods for respiratory surveillance in diacetyl-exposed workers may be preferable to ATS or ACOEM.
评估用于确定接触二乙酰的工人一秒用力呼气容积（FEV1）短期过度下降的方法。
我们评估了五种用于确定接触二乙酰的工人和对照组工人 FEV1 过度纵向下降的方法：美国胸科学会（ATS）、ACOEM 的 8%限制以及基于肺活量数据变异性的相对和绝对纵向限制。评估了相对风险和过度下降的发生率。
使用 ATS 和 ACOEM 标准，对照组中过度 FEV1 下降的发生率为 1%，使用相对纵向下降限制为 4.1%，使用绝对纵向下降限制为 4.4%，使用 8%限制为 5.6%。在所有评估方法中，接触二乙酰工人异常 FEV1 下降的相对风险均升高。
接触二乙酰的工人呼吸监测的替代方法可能优于 ATS 或 ACOEM。
