Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany.
Arch Toxicol. 2010 Dec;84(12):967-78. doi: 10.1007/s00204-010-0617-6. Epub 2010 Nov 10.
Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associated with increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by new data and by meta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95% Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P < 0.0001). However, the odds ratio is relatively small.
单核苷酸多态性 (SNP) rs710521[A]位于 3 号染色体 q28 上的 TP63 附近，被确定与膀胱癌风险增加显著相关。为了通过新数据和包括所有已发表数据的荟萃分析来研究 rs710521[A]与膀胱癌的关联，在德国（n=948/1258）、匈牙利（n=262/65）、委内瑞拉（n=112/190）和巴基斯坦（n=103/227）的 1425 例膀胱癌病例和 1740 例对照中进行了 rs710521 研究，这些样本采集于 1995 年至 2010 年。对 rs710521[A]与膀胱癌风险的关联进行了荟萃分析，纳入了 5695 例病例和 40187 例对照。通过快速实时聚合酶链反应 (rt-PCR) 检测 3 号染色体 q28 位置 191128627 处的 A/G 取代（rs710521）。未校正分析（OR=1.21；95%Cl=1.04-1.40；P=0.011）和校正年龄、性别、吸烟习惯和种族的隐性模型（OR=1.23；95%Cl=1.05-1.44；P=0.010）均显示 rs710521[A]与风险增加相关。在接触和未接触膀胱致癌物质的个体之间，rs710521[A]的相关性没有差异。同样，rs710521[A]在吸烟者和不吸烟者中也没有表现出不同的易感性。对包括所有已发表的 rs710521 研究的 5695 例病例和 40187 例对照进行荟萃分析，得到了与膀胱癌风险相关的令人信服的关联（OR=1.18；95%Cl=1.12-1.25；P<0.0001）。然而，比值比相对较小。
