Nielsen H K, Lundby L, Rasmussen K, Charles P, Hansen C
University Department of Clinical Physiology and Nuclear Medicine, Aarhus Kommunehospital, Denmark.
Calcif Tissue Int. 1990 Mar;46(3):173-8. doi: 10.1007/BF02555040.
The acute effect of 25 and 50 g of alcohol on the variation in serum osteocalcin, a specific and sensitive marker of bone formation, and on serum cortisol and serum parathyroid hormone (PTH)(1-84) was calculated in 6 normal young adults. They were studied during three periods, each lasting from 4 p.m.-7:30 a.m. Alcohol was ingested between 4:15 and 5 p.m. during period two and three. Blood was taken at 4 p.m. and every 15 minutes from 4:30 til 6 p.m., followed by hourly sampling until 12 p.m. The last blood sample was taken after an overnight fast at 7:30 a.m. Initial and end values before and after alcohol ingestion did not differ significantly from control values. Repeated measures analysis of variance showed that 50 g of ethanol decreased serum osteocalcin significantly (P less than 0.02) and increased serum cortisol (P less than 0.05) during the 4-12 p.m. interval. The interaction of 50 g of ethanol on the variation in serum osteocalcin was already significant during the first 2 hours (P less than 0.02), where no significant effect on serum cortisol could be detected. Although insignificant, the same pattern was observed after 25 g of alcohol. There was no significant change in the variation of serum iPTH(1-84) during the 4-6 p.m. after alcohol intake. We conclude that 3-4 drinks of alcohol taken over 45 minutes decreases serum osteocalcin in a dose-dependent way. The time lag between changes in serum osteocalcin and cortisol indicates that the decrease in serum osteocalcin is not related to the increase in serum cortisol.
在6名正常年轻成年人中，计算了25克和50克酒精对血清骨钙素（一种骨形成的特异性和敏感标志物）变化、血清皮质醇和血清甲状旁腺激素（PTH）（1 - 84）的急性影响。他们在三个时间段接受研究，每个时间段从下午4点持续到上午7:30。在第二和第三时间段，下午4:15至5点期间摄入酒精。下午4点采血，从4:30到6点每隔15分钟采血一次，随后每小时采样一次直至晚上12点。最后一份血样在上午7:30空腹过夜后采集。酒精摄入前后的初始值和终值与对照值无显著差异。重复测量方差分析显示，50克乙醇在下午4点至12点期间显著降低血清骨钙素（P小于0.02）并升高血清皮质醇（P小于0.05）。50克乙醇对血清骨钙素变化的影响在最初2小时内已经显著（P小于0.02），此时对血清皮质醇未检测到显著影响。虽然不显著，但25克酒精摄入后也观察到相同模式。酒精摄入后下午4点至6点期间血清iPTH（1 - 84）的变化无显著改变。我们得出结论，在45分钟内摄入3 - 4杯酒精会以剂量依赖的方式降低血清骨钙素。血清骨钙素和皮质醇变化之间的时间滞后表明血清骨钙素的降低与血清皮质醇的升高无关。
