Haley Andreana P, Gonzales Mitzi M, Tarumi Takashi, Miles Steven C, Goudarzi Katayoon, Tanaka Hirofumi
Department of Psychology, The University of Texas at Austin, 1 University Station, A8000, Austin, TX 78712, USA.
Metab Brain Dis. 2010 Dec;25(4):397-405. doi: 10.1007/s11011-010-9221-y. Epub 2010 Nov 10.
Metabolic syndrome (MetS) is a cluster of risk factors associated with significant cardiovascular morbidity and mortality and diminished cognitive function. Given that the cerebral mechanisms mediating the relationship between peripheral metabolic dysfunction and cognitive impairment are unknown, we set out to examine the relationship between diagnosis of metabolic syndrome and cerebral metabolism. Thirteen participants with MetS (aged 48 ± 6 years) and 25 healthy adults (aged 51 ± 6 years) underwent neuropsychological assessment, health screen and proton magnetic resonance spectroscopy ((1)H MRS) examining N-acetyl-aspartate (NAA), myo-inositol (mI), creatine (Cr), choline (Cho), and glutamate (Glu) concentrations in occipitoparietal grey matter. Cerebral metabolite ratios (NAA/Cr, Cho/Cr, mI/Cr, and Glu/Cr) of participants with MetS, defined by the International Diabetes Federation criteria, were compared with controls matched for age, education, cognition, and emotional function. There were no significant differences in global cognitive function, memory, language, and psychomotor performance between the groups. Diagnosis of MetS was associated with significantly higher mI/Cr (F(1,36) = 5.02, p = 0.031) and Glu/Cr ratio (F(1,36) = 4.81, p = 0.035). Even in cognitively normal adults, MetS is related to cerebral metabolic disturbances, a possible indication of early brain vulnerability. Longitudinal studies that begin in mid-life can help validate the use of (1)H MRS markers as indicators of long-term cognitive outcomes.
代谢综合征（MetS）是一组与显著的心血管发病率、死亡率及认知功能减退相关的危险因素。鉴于介导外周代谢功能障碍与认知障碍之间关系的脑机制尚不清楚，我们着手研究代谢综合征的诊断与脑代谢之间的关系。13名患有代谢综合征的参与者（年龄48±6岁）和25名健康成年人（年龄51±6岁）接受了神经心理学评估、健康筛查以及质子磁共振波谱（（1）H MRS）检查，以测定枕顶叶灰质中N-乙酰天门冬氨酸（NAA）、肌醇（mI）、肌酸（Cr）、胆碱（Cho）和谷氨酸（Glu）的浓度。根据国际糖尿病联盟标准定义的代谢综合征参与者的脑代谢物比率（NAA/Cr、Cho/Cr、mI/Cr和Glu/Cr）与年龄、教育程度、认知和情绪功能相匹配的对照组进行比较。两组之间在整体认知功能、记忆、语言和精神运动表现方面没有显著差异。代谢综合征的诊断与显著更高的mI/Cr（F（1,36）=5.02，p = 0.031）和Glu/Cr比率（F（1,36）=4.81，p = 0.035）相关。即使在认知正常的成年人中，代谢综合征也与脑代谢紊乱有关，这可能是早期脑易损性的一个迹象。从中年开始的纵向研究有助于验证使用（1）H MRS标记物作为长期认知结果指标的有效性。
