Suzuki T, Yoshida A
Am J Clin Nutr. 1978 Sep;31(9):1491-8. doi: 10.1093/ajcn/31.9.1491.
The protective and curative effects of dietary iron and ascorbic acid on chronic (180 days) cadmium toxicity in rats were examined. Growth retardation and anemia were observed in rats fed a diet containing 50 ppm of cadmium for 180 days; during this period the contents of iron in the liver, kidney, spleen, testis, intestine, and tibia decreased and the zinc contents of the liver and kidney increased, but the calcium content of bone did not change. Addition of 400 ppm of iron and 1% of ascorbic acid to the cadmium-containing diet overcame the growth retardation and anemia due to cadmium toxicity and reduced the tissue levels of cadmium; however, it did not restore the zinc contents in the liver, kidney, and bone to normal. Similar effects were observed when these compounds were added to cadmium containing diet for 90 days after feeding the cadmium diet alone for 90 days. The glutamic-pyruvic transminase and glutamic-oxaloacetic transminase activities in the plasma of rats fed the cadmium diet increased significantly and these increases were prevented by supplementing the diet with iron and ascorbic acid. Glucose, urea, and alkaline phosphatase in the plasma and glycogen in the liver were not changed by feeding the cadmium diet for 180 days. These results indicate the long-term effectiveness of supplementing the diet with iron and ascorbic-acid for preventing and curing dietary cadmium toxicity in rats.
研究了膳食铁和抗坏血酸对大鼠慢性（180天）镉中毒的保护和治疗作用。给大鼠喂食含50 ppm镉的饲料180天，观察到生长迟缓与贫血现象；在此期间，肝脏、肾脏、脾脏、睾丸、肠道和胫骨中的铁含量下降，肝脏和肾脏中的锌含量增加，但骨骼中的钙含量未发生变化。在含镉饲料中添加400 ppm的铁和1%的抗坏血酸，克服了镉中毒导致的生长迟缓和贫血现象，并降低了组织中的镉含量；然而，它并未使肝脏、肾脏和骨骼中的锌含量恢复正常。在单独喂食镉饲料90天后，再在含镉饲料中添加这些化合物90天，也观察到了类似的效果。喂食镉饲料的大鼠血浆中的谷丙转氨酶和谷草转氨酶活性显著增加，而在饲料中补充铁和抗坏血酸可防止这些增加。喂食镉饲料180天，并未改变血浆中的葡萄糖、尿素和碱性磷酸酶以及肝脏中的糖原含量。这些结果表明，在大鼠饮食中补充铁和抗坏血酸对预防和治疗膳食镉中毒具有长期有效性。
