Suzuki T, Yoshida A
J Nutr. 1979 Jun;109(6):983-8. doi: 10.1093/jn/109.6.982.
In our laboratory, the protective and therapeutic effects of surplus dietary iron and ascorbic acid on cadmium toxicity in rats have been studied and in this experiment, an effect of surplus iron and ascorbic acid on lead toxicity was examined. In young rats ingesting a diet containing 500 ppm of lead, growth retardation and anemia were observed. Suplementation of 400 ppm of iron and 1% of ascorbic acid to the lead containing diet prevented the growth depression and anemia and caused reductions of concentrations of lead in the kidney and tibia. Whereas, addition of 50 ppm of cadmium to the lead containing diet aggravated the growth retardation and anemia, but reduced the concentrations of lead in the kidney and tibia. Dietary supplementation of iron to the lead containing diet prevented the growth depression and anemia and reduced the accumulation of lead in the kidney, however the supplementation of ascorbic acid alone did not show any ameliolative effects. Rats were fed the lead containing diet and then transferred to the basal diet with or without iron and ascorbic acid. Recoveries from the growth retardation and anemia were not observed in rats within a week after the transfer to the non-lead diet with or without iron and ascorbic acid. These results suggest that iron prevents the growth depression and anemia in rats ingesting lead by an inhibition of lead asborption.
在我们实验室，已研究了过量膳食铁和抗坏血酸对大鼠镉毒性的保护和治疗作用，在本实验中，检测了过量铁和抗坏血酸对铅毒性的影响。在摄入含500 ppm铅饮食的幼鼠中，观察到生长迟缓和贫血。向含铅饮食中补充400 ppm铁和1%抗坏血酸可防止生长抑制和贫血，并使肾脏和胫骨中的铅浓度降低。然而，向含铅饮食中添加50 ppm镉会加重生长迟缓与贫血，但降低了肾脏和胫骨中的铅浓度。向含铅饮食中补充铁可防止生长抑制和贫血，并减少肾脏中铅的蓄积，然而单独补充抗坏血酸未显示出任何改善作用。给大鼠喂食含铅饮食，然后将其转移至含或不含铁和抗坏血酸的基础饮食。在转移至含或不含铁和抗坏血酸的无铅饮食一周内，未观察到大鼠的生长迟缓和贫血有所恢复。这些结果表明，铁通过抑制铅吸收来防止摄入铅的大鼠出现生长抑制和贫血。
