Thobani Azzrah, Anastasakis Anastasios, Fishman Gerald A
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago IL, USA.
Ophthalmic Genet. 2010 Dec;31(4):235-9. doi: 10.3109/13816810.2010.518578.
To evaluate structural retinal changes and macular function by a combined spectral domain optical coherence tomography/scanning laser ophthalmoscope (OCT/SLO) microperimetry device in choroideremia carriers.
Ten choroideremia carriers were included in the study. All subjects had a complete ophthalmic examination in addition to Goldmann kinetic visual fields, OCT and microperimetry testing on a commercially available Spectral Domain (SD) OCT/SLO combination system.
Microperimetry results demonstrated focal areas of threshold abnormalities in 50% of the subjects. OCT findings show subtle retinal pigment epithelium (RPE) irregularities with attenuation more pronounced outside the macular region.
Long term follow up with microperimetric testing could be useful in monitoring any progressive loss of retinal function in choroideremia carriers.
通过联合光谱域光学相干断层扫描/扫描激光检眼镜（OCT/SLO）微视野计装置评估脉络膜视网膜病变携带者的视网膜结构变化和黄斑功能。
本研究纳入了10名脉络膜视网膜病变携带者。所有受试者除了进行戈德曼动态视野检查外，还在市售的光谱域（SD）OCT/SLO组合系统上进行了OCT和微视野计测试。
微视野计结果显示50%的受试者存在阈值异常的局部区域。OCT检查结果显示视网膜色素上皮（RPE）有细微不规则，在黄斑区以外衰减更明显。
对脉络膜视网膜病变携带者进行长期微视野计测试随访，可能有助于监测视网膜功能的任何进行性丧失。
