Department of Ophthalmology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Am J Ophthalmol. 2011 Jan;151(1):128-136.e3. doi: 10.1016/j.ajo.2010.06.040. Epub 2010 Oct 20.
To investigate the correlation of microperimetry with fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT), and visual acuity (VA) in order to better characterize visual outcomes after successful macular hole (MH) surgery.
Cross-sectional case series.
Postoperative VA, microperimetry, FAF, and SD-OCT images from 23 eyes of 23 patients who underwent successful MH surgery were obtained. FAF images were examined using the Heidelberg retina angiograph 2, and foveal structure and macular sensitivity were evaluated with SD-OCT and microperimetry. The mean retinal sensitivities within the central 9 degrees (microperimetry, mean), the retinal sensitivity of the foveal center (microperimetry, center), and the difference between the values obtained for the foveal center or mean of study and fellow eyes (microperimetry, centerdiff and microperimetry, meandiff, respectively) were measured with microperimetry.
Microperimetry (mean) was well correlated with microperimetry (center) in both study and fellow eyes. Poor postoperative VA was correlated with large microperimetry (meandiff). Following successful MH surgery, FAF of all eyes decreased markedly. There was a positive correlation between microperimetry (centerdiff) and degree of FAF of study eyes. However, a decrease in FAF after MH surgery was not correlated well with either degree of defect in the junction between photoreceptor inner and outer segment (IS/OS) or central retinal thickness on SD-OCT.
The amount of remaining FAF is related to macular sensitivity as measured by microperimetry after successful MH surgery. Function of photoreceptors and retinal pigment epithelium as well as integrity can be estimated by measuring the decrease in FAF after successful MH surgery. Moreover, functional correlation with microperimetry provides both morphologic and functional information on repaired MHs.
通过对比微视野计、眼底自发荧光（FAF）、频域光相干断层扫描（SD-OCT）和视力（VA），以更好地描述黄斑裂孔（MH）手术后的视力预后。
横断面病例系列。
纳入 23 例（23 只眼）成功接受 MH 手术的患者，收集其术后 VA、微视野计、FAF 和 SD-OCT 图像。采用 Heidelberg 视网膜血管造影仪 2 检查 FAF 图像，用 SD-OCT 和微视野计评估黄斑中心凹结构和黄斑敏感性。微视野计分别测量中心 9 度内的平均视网膜敏感度（微视野计平均）、黄斑中心凹的视网膜敏感度（微视野计中心）以及研究眼和对侧眼的黄斑中心凹或平均值之间的差值（微视野计中心差和微视野计平均差）。
研究眼和对侧眼的微视野计平均与微视野计中心之间具有良好的相关性。术后 VA 较差与微视野计平均差较大有关。所有眼的 FAF 在 MH 手术后均明显降低。研究眼的微视野计中心差与 FAF 程度呈正相关。然而，MH 手术后 FAF 的降低与光感受器内外节（IS/OS）交界处的缺损程度或 SD-OCT 上的中心视网膜厚度均无明显相关性。
MH 手术后剩余 FAF 的量与微视野计测量的黄斑敏感性有关。通过测量 MH 手术后 FAF 的减少，可以评估光感受器和视网膜色素上皮的功能以及完整性。此外，与微视野计的功能相关性为修复后的 MH 提供了形态和功能信息。
