Department of Ophthalmology, Retina Center, New York Eye and Ear Infirmary, Valhalla, NY, USA.
Ophthalmic Res. 2010;43(2):92-8. doi: 10.1159/000247593. Epub 2009 Oct 15.
To investigate the combination of 3D optical coherence tomography (OCT) retinal thickness measurements and superimposed scanning laser ophthalmoscopy (SLO) microperimetry obtained using a Spectral OCT/SLO and to test the correlation between retinal thickness and retinal sensitivity in retinal diseases grouped according to anatomic locations.
Patients with various retinal diseases and subjects with normal fundi underwent microperimetry testing and imaging with the Spectral OCT/SLO. Based on the Spectral OCT/SLO findings, the participants were divided into 4 groups: patients with retinal thickening due to the outer retina pathology (group I); patients with retinal thickening due to the cystic changes observed in the inner retina (group II); patients with macular neurosensory retina thinning associated with geographic atrophy or underlying subretinal cicatricial changes (group III), and subjects with unremarkable fundus appearance and normal appearing retina on Spectral OCT/SLO (group IV). The primary outcome was the correlation coefficient (r) between Spectral OCT/SLO-measured macular thickness and microperimetry values.
Correlations between retinal thickness and psychophysical thresholds were calculated for each patient, and these values were averaged within groups. The mean correlation values (Pearson product movement) were as follows: for group I (n = 21 eyes) r = 0.04; for group II (n = 24 eyes) r = -0.53; for group III (n = 16 eyes) r = 0.41, and for group IV (n = 15 eyes) r = 0.04.
The combination of 3D OCT images and superimposed SLO microperimetry obtained by Spectral OCT/SLO demonstrated that thickening due to cystic changes of the inner retinal layers or thinning of the neurosensory retina on OCT correlated most significantly with decreases in psychophysical threshold sensitivities.
研究使用光谱光学相干断层扫描/扫描激光检眼镜（Spectral OCT/SLO）获得的 3D 光学相干断层扫描（OCT）视网膜厚度测量值和叠加的扫描激光检眼镜（SLO）微视野测量值的组合，并根据解剖位置对视网膜疾病进行分组，测试视网膜厚度与视网膜敏感性之间的相关性。
对各种视网膜疾病患者和眼底正常的受试者进行微视野检查和 Spectral OCT/SLO 成像。根据 Spectral OCT/SLO 的发现，将参与者分为 4 组：由于外视网膜病变导致视网膜增厚的患者（组 I）；由于内视网膜囊样改变导致视网膜增厚的患者（组 II）；与局灶性神经感觉视网膜萎缩或下方视网膜瘢痕性改变相关的黄斑神经感觉视网膜变薄的患者（组 III），以及眼底外观正常且 Spectral OCT/SLO 上视网膜外观正常的受试者（组 IV）。主要结果是 Spectral OCT/SLO 测量的黄斑厚度与微视野值之间的相关系数（r）。
为每位患者计算了视网膜厚度与心理物理阈值之间的相关性，并在组内平均这些值。平均相关值（Pearson 乘积运动）如下：组 I（n=21 只眼）r=0.04；组 II（n=24 只眼）r=-0.53；组 III（n=16 只眼）r=0.41，组 IV（n=15 只眼）r=0.04。
Spectral OCT/SLO 获得的 3D OCT 图像和叠加的 SLO 微视野相结合表明，内视网膜层的囊样改变或 OCT 上的神经感觉视网膜变薄导致的增厚与心理物理阈值敏感性的降低最显著相关。
