HIV-1 Nef蛋白通过巨噬细胞纳米管进入B细胞：这是艾滋病相关淋巴瘤发病机制之一？
HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis?
作者信息
Lamers Susanna L, Fogel Gary B, Huysentruyt Leanne C, McGrath Michael S
机构信息
Polytechnic Institute of New York University, Brooklyn, NY, USA.
出版信息
Curr HIV Res. 2010 Dec;8(8):638-40. doi: 10.2174/157016210794088209.
Abstract
This letter refers to the recent demonstration that HIV-1 infected macrophages form specialized conduits that connect to B-cells (1). The conduit selectively transports the HIV-1 nef protein, providing nef with numerous means to interfere with cellular processes. Currently, no consideration of the connection between the conduit and the development of AIDS-related lymphoma (ARL) has been offered. ARL is one of the primary causes of death in the HIV-infected population and is related to B-cell proliferation and activation. In this letter we discuss several studies that link HIV-infected macrophages and specific forms of the nef protein to the development of ARL. The conduits discovered by Xu et al. may lead to a better understanding of how HIV infection results in lymphomagenesis.
摘要
这封信涉及最近的一项证明，即感染HIV-1的巨噬细胞形成与B细胞相连的特殊管道(1)。该管道选择性地运输HIV-1 nef蛋白，为nef提供了许多干扰细胞过程的手段。目前，尚未有人考虑该管道与艾滋病相关淋巴瘤(ARL)发展之间的联系。ARL是HIV感染人群的主要死亡原因之一，与B细胞增殖和激活有关。在这封信中，我们讨论了几项将HIV感染的巨噬细胞和特定形式的nef蛋白与ARL发展联系起来的研究。Xu等人发现的这些管道可能有助于更好地理解HIV感染如何导致淋巴瘤发生。
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