Department of Medicine, Hematology and Oncology, University of California, San Francisco, California, USA.
J Leukoc Biol. 2010 Apr;87(4):627-32. doi: 10.1189/jlb.0809564. Epub 2009 Dec 30.
Despite HAART, patients infected with HIV develop NHL at a significantly higher level than the noninfected population. The primary difference between lymphoma in non-HIV-infected individuals and those with ARL is that ARL is consistently high-grade and metastatic. The emergence of ARL is associated with the presence of macrophage viral reservoirs, similar to what has been observed for HAD. HIV-infected macrophages, as seen by histology and HIV p24 staining, are present in approximately half of ARLs. Macrophage reservoirs recruit additional immune cells, including monocytes/macrophages, through the release of chemoattractants. Additionally, TAM are known to promote tumor progression for most cancer types, including lymphomas. This review will highlight and discuss the role of macrophage viral reservoirs in the development and progression of ARLs and hopefully, shed light on this new and interesting field.
尽管采用了高效抗逆转录病毒治疗（HAART），感染 HIV 的患者发生 NHL 的水平仍明显高于未感染者。非 HIV 感染者和 AIDS 相关淋巴瘤（ARL）患者之间的淋巴瘤主要区别在于，ARL 始终为高级别且转移性。ARL 的出现与巨噬细胞病毒储库的存在有关，这与 HAD 的观察结果相似。通过组织学和 HIV p24 染色观察到，大约一半的 ARL 中存在感染 HIV 的巨噬细胞。巨噬细胞储库通过释放趋化因子招募其他免疫细胞，包括单核细胞/巨噬细胞。此外，TAM 已知可促进大多数癌症类型（包括淋巴瘤）的肿瘤进展。本综述将重点讨论并探讨巨噬细胞病毒储库在 ARL 发展和进展中的作用，并希望能为这一新的有趣领域提供一些启示。
