Department of Medicine, DVA Puget Sound Health Care System, Seattle, WA 98108, USA.
Clin Chem. 2011 Feb;57(2):158-61. doi: 10.1373/clinchem.2010.148270. Epub 2010 Nov 10.
Diabetes mellitus has been historically divided into type 1 and type 2 diabetes, with type 1 being an autoimmune disease and type 2 being primarily a metabolic disease.
The current diabetes classification scheme needs to be reevaluated because of the accumulating evidence of immune system involvement in the pathophysiology of type 2 diabetes.
There are similarities and differences between type 1 and type 2 diabetes with regard to pathogenesis, pathophysiology, and genetics. We propose a resolution to the dilemma of the current classification scheme.
糖尿病在历史上被分为 1 型和 2 型糖尿病，其中 1 型糖尿病是一种自身免疫性疾病，2 型糖尿病主要是一种代谢性疾病。
由于免疫系统参与 2 型糖尿病病理生理学的证据不断积累，目前的糖尿病分类方案需要重新评估。
1 型和 2 型糖尿病在发病机制、病理生理学和遗传学方面既有相似之处，也有不同之处。我们提出了解决当前分类方案困境的方案。
