临床免疫学评论系列；关注代谢疾病：2 型糖尿病患者胰岛自身免疫疾病的发展：慢性炎症的潜在后果。
Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation.
机构信息
Department of Medicine, University of Washington, Seattle, WA, USA.
出版信息
Clin Exp Immunol. 2012 Jan;167(1):40-6. doi: 10.1111/j.1365-2249.2011.04501.x.
Abstract
Historically, the development of type 2 diabetes has been considered not to have an autoimmune component, in contrast to the autoimmune pathogenesis of type 1 diabetes. In this review we will discuss the accumulating data supporting the concept that islet autoreactivity and inflammation is present in type 2 diabetes pathogenesis, and the islet autoimmunity appears to be one of the factors associated with the progressive nature of the type 2 diabetes disease process.
摘要
从历史上看，2 型糖尿病的发展被认为没有自身免疫成分，与 1 型糖尿病的自身免疫发病机制形成对比。在这篇综述中，我们将讨论支持胰岛自身反应性和炎症存在于 2 型糖尿病发病机制中的累积数据，并讨论胰岛自身免疫似乎是与 2 型糖尿病病程进展性质相关的因素之一。
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