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Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation.临床免疫学评论系列；关注代谢疾病：2 型糖尿病患者胰岛自身免疫疾病的发展：慢性炎症的潜在后果。
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[The immunological aspects of the development of diabetes mellitus and its complications].
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Dual roles of immune cells and their factors in cancer development and progression.免疫细胞及其因子在癌症发生发展中的双重作用。
Int J Biol Sci. 2011;7(5):651-8. doi: 10.7150/ijbs.7.651. Epub 2011 May 21.
2
Role of innate immunity in diabetes and metabolism: recent progress in the study of inflammasomes.先天免疫在糖尿病和代谢中的作用：炎症小体研究的最新进展。
Immune Netw. 2011 Apr;11(2):95-9. doi: 10.4110/in.2011.11.2.95. Epub 2011 Apr 30.
3
Mechanisms that regulate peripheral immune responses to control organ-specific autoimmunity.调节外周免疫反应以控制器官特异性自身免疫的机制。
Clin Dev Immunol. 2011;2011:294968. doi: 10.1155/2011/294968. Epub 2011 Apr 28.
4
Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages.人原代脂肪细胞表现出免疫细胞功能：脂肪细胞在不依赖巨噬细胞的情况下引发炎症。
PLoS One. 2011 Mar 23;6(3):e17154. doi: 10.1371/journal.pone.0017154.
5
Pioglitazone for diabetes prevention in impaired glucose tolerance.吡格列酮用于改善葡萄糖耐量受损的糖尿病预防。
N Engl J Med. 2011 Mar 24;364(12):1104-15. doi: 10.1056/NEJMoa1010949.
6
Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers.肥胖症内脏脂肪炎症与调节性 T 细胞数量的关键改变有关。
PLoS One. 2011 Jan 26;6(1):e16376. doi: 10.1371/journal.pone.0016376.
7
Type 2 diabetes as an inflammatory disease.2 型糖尿病作为一种炎症性疾病。
Nat Rev Immunol. 2011 Feb;11(2):98-107. doi: 10.1038/nri2925. Epub 2011 Jan 14.
8
Is diabetes mellitus a continuous spectrum?糖尿病是一种连续谱吗？
Clin Chem. 2011 Feb;57(2):158-61. doi: 10.1373/clinchem.2010.148270. Epub 2010 Nov 10.
9
PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice.过氧化物酶体增殖物激活受体 γ 的激活可减轻肥胖小鼠 T 淋巴细胞依赖性脂肪组织炎症和胰岛素抵抗的发生。
Cardiovasc Diabetol. 2010 Oct 18;9:64. doi: 10.1186/1475-2840-9-64.
10
Identification of autoantibody-negative autoimmune type 2 diabetic patients.自身抗体阴性的自身免疫性 2 型糖尿病患者的鉴定。
Diabetes Care. 2011 Jan;34(1):168-73. doi: 10.2337/dc10-0579. Epub 2010 Sep 20.

临床免疫学评论系列；关注代谢疾病：2 型糖尿病患者胰岛自身免疫疾病的发展：慢性炎症的潜在后果。

Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation.

机构信息

Department of Medicine, University of Washington, Seattle, WA, USA.

出版信息

Clin Exp Immunol. 2012 Jan;167(1):40-6. doi: 10.1111/j.1365-2249.2011.04501.x.

DOI:10.1111/j.1365-2249.2011.04501.x
PMID:22132883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3248085/
Abstract

Historically, the development of type 2 diabetes has been considered not to have an autoimmune component, in contrast to the autoimmune pathogenesis of type 1 diabetes. In this review we will discuss the accumulating data supporting the concept that islet autoreactivity and inflammation is present in type 2 diabetes pathogenesis, and the islet autoimmunity appears to be one of the factors associated with the progressive nature of the type 2 diabetes disease process.

摘要

从历史上看，2 型糖尿病的发展被认为没有自身免疫成分，与 1 型糖尿病的自身免疫发病机制形成对比。在这篇综述中，我们将讨论支持胰岛自身反应性和炎症存在于 2 型糖尿病发病机制中的累积数据，并讨论胰岛自身免疫似乎是与 2 型糖尿病病程进展性质相关的因素之一。