Hebden J C, Hall D J, Firbank M, Delpy D T
Appl Opt. 1995 Dec 1;34(34):8038-47. doi: 10.1364/AO.34.008038.
A solid plastic phantom has been developed with optical properties that closely match those of human breast tissue at near-IR wavelengths. The phantom is a 54-mm-thick slab containing four small cylinders of contrasting scatter and absorption. A detailed description of the phantom is followed by an account of an attempt to image the phantom by a time-resolved imaging technique. Images generated with transmitted light with the shortest flight times revealed the embedded cylinders with greater visibility than images obtained with continuous light transillumination. However, images corresponding to flight times of less than ~700 ps were severely degraded from a lack of detected photons. An attempt was made to overcome this degradation by extrapolating the measured temporal distributions with an analytic model of photon transport. Results suggest that subcentimeter resolution imaging of low-contrast tumors in the breast is scientifically possible. Our phantom is available to any other research groups wishing to evaluate their systems.
已经开发出一种固体塑料模型，其光学特性在近红外波长下与人类乳腺组织的光学特性非常匹配。该模型是一个54毫米厚的平板，包含四个具有不同散射和吸收特性的小圆柱体。在对该模型进行详细描述之后，介绍了一种尝试使用时间分辨成像技术对该模型进行成像的过程。用飞行时间最短的透射光生成的图像显示，与连续光透照获得的图像相比，嵌入的圆柱体具有更高的可见度。然而，由于检测到的光子不足，对应于飞行时间小于约700皮秒的图像严重退化。尝试通过用光子传输分析模型外推测量的时间分布来克服这种退化。结果表明，对乳腺中低对比度肿瘤进行亚厘米分辨率成像在科学上是可行的。我们的模型可供任何希望评估其系统的其他研究小组使用。
