Wang Hai-Jun, Gu Fang, Hong Xiao-Zhong, Ba Xin-Wu
Hebei University, Baoding, China.
Eur Phys J E Soft Matter. 2010 Nov;33(3):251-8. doi: 10.1140/epje/i2010-10663-6. Epub 2010 Oct 31.
The cooperative translocation dynamics of two complementary single-stranded DNA chains through two nanopores located in a membrane is investigated theoretically. The translocation process is considered to be quasi-equilibrium, and then under the limit of slow dynamics the average translocation times are numerically presented under different conditions. It is shown that the effects of the chemical potential gradient, the recombination energy and the distance between the two nanopores on the cooperative translocation are significant. The present model predicts that the cooperative translocation of such two chains can shorten the translocation time, reduce the backward motion and thus improve the translocation efficiency.
从理论上研究了两条互补单链DNA链通过位于膜中的两个纳米孔的协同转位动力学。转位过程被认为是准平衡的，然后在慢动力学极限下，给出了不同条件下的平均转位时间的数值结果。结果表明，化学势梯度、重组能以及两个纳米孔之间的距离对协同转位的影响显著。本模型预测，这样两条链的协同转位可以缩短转位时间，减少向后运动，从而提高转位效率。
