Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Head Neck. 2011 May;33(5):719-26. doi: 10.1002/hed.21531. Epub 2010 Nov 10.
Pituitary tumor transforming gene (PTTG1) is overexpressed in many types of human cancers and is involved in late-stage tumor progression. The role of PTTG1 in initiating tumorigenesis is unclear.
PTTG1 expression was assessed in precancerous lesions and squamous cell carcinomas of the oral cavity (OSCC). The association between the protein expression and clinicopathologic parameters was analyzed. The expression level of PTTG1 upon carcinogen treatment was also investigated.
PTTG1 was overexpressed in both precancerous lesions and OSCC. The expression of PTTG1 was associated with carcinogen exposure in vivo and in vitro. PTTG1 overexpression was an independent factor for oral cancer development in precancerous lesions.
This study provides the first evidence that PTTG1 is involved in the early stages of oral tumorigenesis. Carcinogen exposure may cause the initial induction of PTTG1 expression in oral precancerous lesions. PTTG1 overexpression is a potential prognosticator for malignant progression of oral precancerous lesions.
垂体肿瘤转化基因（PTTG1）在多种人类癌症中过度表达，参与晚期肿瘤进展。PTTG1 在引发肿瘤发生中的作用尚不清楚。
评估口腔癌（OSCC）癌前病变和鳞状细胞癌中 PTTG1 的表达。分析蛋白表达与临床病理参数之间的关系。还研究了致癌物处理后 PTTG1 的表达水平。
PTTG1 在癌前病变和 OSCC 中均过度表达。PTTG1 的表达与体内和体外致癌物暴露有关。PTTG1 过表达是癌前病变中口腔癌发展的独立因素。
本研究首次提供证据表明 PTTG1 参与口腔肿瘤发生的早期阶段。致癌物暴露可能导致口腔癌前病变中 PTTG1 表达的初始诱导。PTTG1 过表达是口腔癌前病变恶性进展的潜在预后因子。
