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儿童阻塞性睡眠呼吸暂停低通气综合征中的QT离散度

QT dispersion in childhood obstructive sleep apnoea syndrome.

作者信息

Khositseth Anant, Nantarakchaikul Palinee, Kuptanon Teeradej, Preutthipan Aroonwan

机构信息

Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Cardiol Young. 2011 Apr;21(2):130-5. doi: 10.1017/S1047951110001514. Epub 2010 Nov 12.

Abstract

The difference between maximal and minimal QT interval and corrected QT interval defined as QT dispersion and corrected QT dispersion may represent arrhythmogenic risks. This study sought to evaluate QT dispersion and corrected QT dispersion in childhood obstructive sleep apnoea syndrome. Forty-four children (34 male) with obstructive sleep apnoea syndrome, aged 6.2 plus or minus 3.5 years along with 38 healthy children (25 male), 6.6 plus or minus 2.1 years underwent electrocardiography to measure QT and RR intervals. Means QT dispersion and corrected QT dispersion were significantly higher in obstructive sleep apnoea syndrome than controls, 52 plus or minus 27 compared to 40 plus or minus 14 milliseconds (p equal to 0.014), and 71 plus or minus 29 compared to 57 plus or minus 19 milliseconds (p equal to 0.010), respectively. Interestingly, QT dispersion and corrected QT dispersion in obstructive sleep apnoea syndrome with obesity, 57 plus or minus 30 and 73 plus or minus 31 milliseconds, were significantly higher than in control, 40 plus or minus 14 and 57 plus or minus 19 milliseconds (p equal to 0.009 and 0.043, respectively). However, QT dispersion and corrected QT dispersion in obstructive sleep apnoea syndrome without obesity, 43 plus or minus 20 and 68 plus or minus 26 milliseconds, were not significantly different. In conclusion, QT dispersion and corrected QT dispersion were significantly increased only in childhood obstructive sleep apnoea syndrome with obesity. Obesity may be the factor affecting the increased QT dispersion and corrected QT dispersion.

摘要

最大QT间期与最小QT间期之差以及校正QT间期(定义为QT离散度和校正QT离散度)可能代表致心律失常风险。本研究旨在评估儿童阻塞性睡眠呼吸暂停综合征中的QT离散度和校正QT离散度。44名患有阻塞性睡眠呼吸暂停综合征的儿童(34名男性),年龄为6.2±3.5岁,以及38名健康儿童(25名男性),年龄为6.6±2.1岁,接受了心电图检查以测量QT和RR间期。阻塞性睡眠呼吸暂停综合征患者的平均QT离散度和校正QT离散度显著高于对照组,分别为52±27毫秒和40±14毫秒(p = 0.014),以及71±29毫秒和57±19毫秒(p = 0.010)。有趣的是,肥胖的阻塞性睡眠呼吸暂停综合征患者的QT离散度和校正QT离散度分别为57±30毫秒和73±31毫秒,显著高于对照组的40±14毫秒和57±19毫秒(分别为p = 0.009和0.043)。然而,非肥胖的阻塞性睡眠呼吸暂停综合征患者的QT离散度和校正QT离散度分别为43±20毫秒和68±26毫秒,无显著差异。总之,仅在肥胖的儿童阻塞性睡眠呼吸暂停综合征中,QT离散度和校正QT离散度显著增加。肥胖可能是影响QT离散度和校正QT离散度增加的因素。

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