Ogata Kiyokazu, Warita Sachie, Shimazu Kisaki, Kawakami Tomomi, Aoyagi Kyoko, Karibe Hiroyuki
Department of Pediatric Dentistry, School of Life Dentistry at Tokyo, Nippon Dental University, Tokyo, Japan.
Pediatr Dent. 2010 Sep-Oct;32(5):433-8.
The purpose of this study was to show through enamel remineralization that a combination of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and fluoride is better than fluoride alone when the processing time for remineralization is short.
The bovine enamel slabs (n=28) were subjected to pH cycling for 4 days. Paste containing CPP-ACP and/or fluoride was applied for 30 minutes daily. The sections were observed using a polarizing microscope and microradiographs.
In the groups treated solely with sodium fluoride (NaF) solution, tissue loss on the enamel surface was observed. On the other hand, in the groups that had been treated with a mixture of the NaF solution and CPP-ACP, the enamel surface was maintained.
These results show that casein phosphopeptide-amorphous calcium phosphate-containing paste has the ability to maintain the enamel surface; the combined use of CPP-ACP paste and fluoride enhances this ability, thereby reducing demineralization.
本研究的目的是通过牙釉质再矿化表明，当再矿化处理时间较短时，酪蛋白磷酸肽 - 无定形磷酸钙（CPP - ACP）与氟化物的组合比单独使用氟化物效果更好。
将牛牙釉质片（n = 28）进行4天的pH循环处理。每天涂抹含CPP - ACP和/或氟化物的糊剂30分钟。使用偏光显微镜和显微放射照片观察切片。
在仅用氟化钠（NaF）溶液处理的组中，观察到牙釉质表面的组织损失。另一方面，在用NaF溶液和CPP - ACP混合物处理的组中，牙釉质表面得以维持。
这些结果表明，含酪蛋白磷酸肽 - 无定形磷酸钙的糊剂具有维持牙釉质表面的能力；CPP - ACP糊剂与氟化物的联合使用增强了这种能力，从而减少脱矿。
