Gar'kavyĭ M I, Kovner F Ia
Antibiotiki. 1978 Aug;23(8):756-60.
Karminomycin effect on the activity of some serum enzymes, such as hexokinase (HK), lactate dehydrogenase (LDG), its isoenzymes and glucose-6-phosphatase (G-6-P-ase) was studied. Biochemical assays were applied to 52 patients with neglected malignant tumors. The course dose of the drug was on the average 72mg. The objective antitumor effect was registered in 15 patients. A reliable increase in the values of LDG-5 and G-6-P-ase was observed after the treatment course in the combined group consisting of all the patients subjected to the biochemical assay. Normalization of the serum enzyme spectrum was observed in 15 patients effectively treated with karminomycin: activity of HK and the cathode fractions of LDG decreased. When treatment with karminomycin was ineffective (37 cases), the changes in the enzymatic activity recorded before the treatment further aggraviated. It was found that the level of G-6-P-ase in the patients' treated with karminomycin increased independent of the treatment effect which was probably associated with its toxic effect on the liver. The increase was reversible.
研究了卡米诺霉素对某些血清酶活性的影响，这些酶包括己糖激酶（HK）、乳酸脱氢酶（LDG）及其同工酶以及葡萄糖-6-磷酸酶（G-6-P-ase）。对52例晚期恶性肿瘤患者进行了生化检测。该药物的疗程剂量平均为72mg。15例患者出现了客观的抗肿瘤效果。在对所有接受生化检测的患者组成的联合组进行疗程治疗后，观察到LDG-5和G-6-P-ase值有可靠的升高。在用卡米诺霉素有效治疗的15例患者中观察到血清酶谱正常化：HK活性和LDG的阴极部分降低。当卡米诺霉素治疗无效时（37例），治疗前记录的酶活性变化进一步加重。发现用卡米诺霉素治疗的患者中G-6-P-ase水平升高，且与治疗效果无关，这可能与其对肝脏的毒性作用有关。这种升高是可逆的。
