Durnov L A, Susuleva N A, Lichinitser M R
Antibiotiki. 1976 Jul;21(7):654-7.
Side reactions and therapeutic effect of carminomycin were studied in 21 children with various malignant tumors. Carminomycin was administered intravenously in doses of 0.15-0.2 mg/kg twice a week for 2-3 weeks. The treatment courses were repeated in a month. The drug was better tolerated by children than by adults. After the treatment course leucopenia may develop. When used alone or in combination with vincristin or cyclophosphan carminomycin proved to be effective in treatment of sarcoma of the soft tissues (liposarcoma, synovial sarcoma), chondrosarcoma and reticulosarcoma.
对21例患有各种恶性肿瘤的儿童进行了洋红霉素的副作用及治疗效果研究。洋红霉素静脉给药，剂量为0.15 - 0.2毫克/千克，每周两次，共2 - 3周。治疗疗程一个月后重复进行。儿童对该药物的耐受性优于成人。治疗疗程后可能会出现白细胞减少。单独使用或与长春新碱或环磷酰胺联合使用时，洋红霉素在治疗软组织肉瘤（脂肪肉瘤、滑膜肉瘤）、软骨肉瘤和网状细胞肉瘤方面被证明是有效的。
