Lichinitser M R, Assekritova I V, Gorbunova V A, Arseriĭ S A, Vaarik Kh M
Antibiotiki. 1978 May;23(5):453-7.
Karminomycin was used for the treatment of cases with disseminated cancer of the mammary gland in doses of 5 mg/m2 of the body surface intravenously every day for 5 days (15 patients) or 6 mg/m2 twice a week for 2-3 weeks (30 patients). Partial remission or diminution of the tumor size at least by 50 per cent was observed in 26 and 17 per cent of the patients respectively. The remission duration was from 2 to 6 months. With the use of the shortperiod scheme the frequency of the direct side reactions increased. Leucopenia as a side effect was registered in 100 and 40 per cent of the patients and thrombocytopenia was registered in 18 and 3 per cent of the cases respectively.
卡米诺霉素用于治疗弥漫性乳腺癌患者,剂量为每天5毫克/平方米体表面积,静脉注射,共5天(15例患者),或每周两次,每次6毫克/平方米,持续2 - 3周(30例患者)。分别在26%和17%的患者中观察到部分缓解或肿瘤大小至少缩小50%。缓解期为2至6个月。采用短期方案时,直接副作用的发生率增加。分别有100%和40%的患者出现白细胞减少这一副作用,18%和3%的病例出现血小板减少。