Benson Dennis A, Karsch-Mizrachi Ilene, Lipman David J, Ostell James, Sayers Eric W
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Nucleic Acids Res. 2011 Jan;39(Database issue):D32-7. doi: 10.1093/nar/gkq1079. Epub 2010 Nov 10.
GenBank® is a comprehensive database that contains publicly available nucleotide sequences for more than 380,000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system that integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage: www.ncbi.nlm.nih.gov.
GenBank®是一个综合数据库，包含超过38万个已命名到属或更低分类级别的生物的公开可用核苷酸序列，这些序列主要通过各个实验室的提交以及大规模测序项目（包括全基因组鸟枪法测序（WGS）和环境采样项目）的批量提交获得。大多数提交是使用基于网络的BankIt程序或独立的Sequin程序进行的，GenBank工作人员在收到提交后会分配登录号。与欧洲核苷酸档案馆（ENA）和日本DNA数据库（DDBJ）的每日数据交换确保了全球范围的覆盖。GenBank可通过NCBI Entrez检索系统访问，该系统整合了来自主要DNA和蛋白质序列数据库的数据，以及分类学、基因组、图谱、蛋白质结构和结构域信息，还通过PubMed整合了生物医学期刊文献。BLAST可对GenBank和其他序列数据库进行序列相似性搜索。GenBank数据库每两个月进行一次完整发布，并通过FTP进行每日更新。要访问GenBank及其相关的检索和分析服务，请从NCBI主页开始：www.ncbi.nlm.nih.gov。
