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Novel pharmacological approaches to treatment of drug overdose and addiction.

作者信息

Zhan Chang-Guo

机构信息

University of Kentucky, Department of Pharmaceutical Sciences, College of Pharmacy, 789 South Limestone Street, Lexington, KY 40536, USA TEL: 859-323-3943 FAX: 859-323-3575

出版信息

Expert Rev Clin Pharmacol. 2009;2(1):1-4. doi: 10.1586/17512433.2.1.1.

DOI:10.1586/17512433.2.1.1
PMID:21072135
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2975360/
Abstract
摘要

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本文引用的文献

1
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.用于长期预防可卡因毒性的可卡因酯酶热稳定变体。
Mol Pharmacol. 2009 Feb;75(2):318-23. doi: 10.1124/mol.108.049486. Epub 2008 Nov 5.
2
Most efficient cocaine hydrolase designed by virtual screening of transition states.通过过渡态虚拟筛选设计的最有效的可卡因水解酶。
J Am Chem Soc. 2008 Sep 10;130(36):12148-55. doi: 10.1021/ja803646t. Epub 2008 Aug 19.
3
A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats.一种由人丁酰胆碱酯酶改造而来的可卡因水解酶可选择性地阻断可卡因毒性，并抑制大鼠复吸觅药行为。
Neuropsychopharmacology. 2008 Oct;33(11):2715-25. doi: 10.1038/sj.npp.1301666. Epub 2008 Jan 16.
4
Free energy perturbation (FEP) simulation on the transition states of cocaine hydrolysis catalyzed by human butyrylcholinesterase and its mutants.关于人丁酰胆碱酯酶及其突变体催化可卡因水解过渡态的自由能微扰（FEP）模拟。
J Am Chem Soc. 2007 Nov 7;129(44):13537-43. doi: 10.1021/ja073724k. Epub 2007 Oct 10.
5
Cocaine esterase: interactions with cocaine and immune responses in mice.可卡因酯酶：与小鼠体内可卡因的相互作用及免疫反应
J Pharmacol Exp Ther. 2007 Feb;320(2):926-33. doi: 10.1124/jpet.106.114223. Epub 2006 Nov 17.
6
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase.细菌可卡因酯酶对大鼠可卡因诱导的致死性具有快速且强大的保护作用。
Mol Pharmacol. 2006 Dec;70(6):1885-91. doi: 10.1124/mol.106.025999. Epub 2006 Sep 12.
7
Modeling effects of oxyanion hole on the ester hydrolysis catalyzed by human cholinesterases.模拟氧阴离子空穴对人胆碱酯酶催化酯水解的影响。
J Phys Chem B. 2005 Dec 8;109(48):23070-6. doi: 10.1021/jp053736x.
8
Molecular dynamics simulation of cocaine binding with human butyrylcholinesterase and its mutants.可卡因与人丁酰胆碱酯酶及其突变体结合的分子动力学模拟
J Phys Chem B. 2005 Mar 17;109(10):4776-82. doi: 10.1021/jp0447136.
9
Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation.基于过渡态模拟的用于加速可卡因水解的人丁酰胆碱酯酶突变体的计算设计。
Angew Chem Int Ed Engl. 2006 Jan 16;45(4):653-7. doi: 10.1002/anie.200503025.
10
Catalytic mechanism and energy barriers for butyrylcholinesterase-catalyzed hydrolysis of cocaine.丁酰胆碱酯酶催化可卡因水解的催化机制和能垒。
Biophys J. 2005 Dec;89(6):3863-72. doi: 10.1529/biophysj.105.070276.