Grammer L C, Roberts M, Lerner C, Patterson R
Department of Medicine, Northwestern University Medical School, Chicago, Ill. 60611.
J Allergy Clin Immunol. 1990 Mar;85(3):655-60. doi: 10.1016/0091-6749(90)90107-f.
We report the clinical and serologic findings in four children and five adults with chronic avian hypersensitivity pneumonitis. All subjects were treated with corticosteroids and bird exposure was reduced or eliminated. After a variable period, ranging from 6 months to 10 years, their clinical and serologic findings were reassessed. In terms of symptomatology, chest findings, and pulmonary functions, all four children improved and four adults improved, whereas one adult had a progressive clinical deterioration, ultimately resulting in her death 5 years later. In terms of serologic data, precipitating antibody tended to persist, and antibody to avian antigens, as determined by ELISA, remained positive, although the titer declined. We conclude that, while serologic positivity remains, the prognosis for children and adults with chronic avian hypersensitivity pneumonitis is very good, provided that irreversible damage has not already occurred at the time of diagnosis.
我们报告了4名儿童和5名成人慢性禽鸟过敏性肺炎的临床和血清学检查结果。所有受试者均接受了皮质类固醇治疗，并减少或避免了与鸟类接触。经过6个月至10年不等的一段时间后，对他们的临床和血清学检查结果进行了重新评估。在症状学、胸部检查结果和肺功能方面，4名儿童和4名成人病情有所改善，而1名成人病情出现进行性临床恶化，最终在5年后死亡。在血清学数据方面，沉淀抗体往往持续存在，通过酶联免疫吸附测定（ELISA）检测的针对禽鸟抗原的抗体仍为阳性，尽管滴度有所下降。我们得出结论，虽然血清学呈阳性，但只要在诊断时尚未发生不可逆转的损害，慢性禽鸟过敏性肺炎儿童和成人的预后非常良好。
