Department of Chemical Engineering, Universitat Politécnica de Catalunya, Escola Universitária d'Enginyeria Tècnica Industrial, Terrassa, Spain.
Adv Biochem Eng Biotechnol. 2011;125:1-27. doi: 10.1007/10_2010_93.
Naturally derived polymers possess a number of properties beneficial to wound healing and tissue engineering. The polysaccharides chitin and chitosan appear to be suitable candidates for the preparation of dressing materials and scaffolds for tissue regeneration due to their unique structural, physico-chemical and functional properties. Functionalization of these biopolymers for improvement of properties such as solubility or introduction of active functions and blending with other intrinsically bioactive polymers has attracted considerable attention in recent years. Such modifications would allow going beyond traditional approaches for treatments of dermal injuries. This chapter is a critical review of the advances in chitin and chitosan functionalization for wound-healing and tissue-engineering applications.
天然聚合物具有许多有益于伤口愈合和组织工程的特性。甲壳素和壳聚糖等多糖似乎是制备敷料材料和组织再生支架的合适候选材料，因为它们具有独特的结构、物理化学和功能特性。近年来，这些生物聚合物的功能化引起了相当大的关注，目的是改善其性能，如提高其溶解性或引入活性功能，并与其他具有内在生物活性的聚合物进行共混。这些修饰将允许超越传统的治疗皮肤损伤的方法。本章是对壳聚糖和壳聚糖功能化在伤口愈合和组织工程应用中的进展的批判性回顾。
