Division of Gastroenterology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehang-ro, Jongno-gu, Seoul, 110-744, South Korea.
World J Gastroenterol. 2010 Nov 14;16(42):5347-52. doi: 10.3748/wjg.v16.i42.5347.
To compare the efficacy of self-expandable metal stents (SEMSs) with 10F plastic stents (PSs) in the endoscopic management of occluded SEMSs.
We retrospectively reviewed the medical records of 56 patients who underwent SEMS insertion for palliation of unresectable malignant biliary obstruction between 2000 and 2007 and subsequent endoscopic retrograde biliary drainage (ERBD) with SEMS or PS for initial SEMS occlusion between 2000 and 2008.
Subsequent ERBD with SEMS was performed in 29 patients and with PS in 27. The median time to stent occlusion after subsequent ERBD was 186 d in the SEMS group and 101 d in the PS group (P = 0.118). Overall median stent patency was 79 d for the SEMS group and 66 d for the PS group (P = 0.379). The mean number of additional biliary drainage procedures after subsequent ERBD in patients that died (n = 50) during the study period was 2.54 ± 4.12 for the SEMS group and 1.85 ± 1.95 for the PS group (P = 0.457). The mean total cost of additional biliary drainage procedures after the occlusion of subsequent SEMS or PS was $410.04 ± 692.60 for the SEMS group and $630.16 ± 671.63 for the PS group (P = 0.260). Tumor ingrowth as the cause of initial SEMS occlusion was the only factor associated with a shorter time to subsequent stent occlusion (101 d for patients with tumor ingrowth vs 268 d for patients without tumor ingrowth, P = 0.008).
Subsequent ERBD with PSs offered similar patency and number of additional biliary drainage procedures compared to SEMSs in the management of occluded SEMS.
比较自膨式金属支架(SEMS)与 10F 塑料支架(PS)在治疗阻塞性 SEMS 内镜管理中的疗效。
我们回顾性分析了 2000 年至 2007 年间因不可切除的恶性胆道梗阻而行 SEMS 置入姑息治疗的 56 例患者的病历记录,并对 2000 年至 2008 年间首次 SEMS 阻塞行内镜逆行胆管引流(ERBD)时采用 SEMS 或 PS 的情况进行了分析。
29 例患者行后续 SEMS ERBD,27 例患者行 PS ERBD。SEMS 组和 PS 组支架再阻塞后的中位时间分别为 186d 和 101d(P = 0.118)。SEMS 组和 PS 组的中位支架通畅时间分别为 79d 和 66d(P = 0.379)。在研究期间死亡(n = 50)的患者中,在后续 ERBD 后需要进行额外胆道引流的平均次数为 SEMS 组 2.54 ± 4.12 次,PS 组 1.85 ± 1.95 次(P = 0.457)。SEMS 或 PS 阻塞后,额外胆道引流的总费用为 SEMS 组 410.04 ± 692.60 美元,PS 组 630.16 ± 671.63 美元(P = 0.260)。肿瘤生长是导致初始 SEMS 阻塞的唯一因素,与后续支架阻塞时间较短有关(肿瘤生长患者的时间为 101d,无肿瘤生长患者的时间为 268d,P = 0.008)。
在治疗阻塞性 SEMS 时,PS 行 ERBD 与 SEMS 相比,具有相似的通畅率和需要进行额外胆道引流的次数。