Magosso Enrico, Ansari Mukhtar Alam, Gopalan Yogheswaran, Abu Bakar Mohamed Rizal, Karim Khan Nurzalina Abdul, Wong Jia Woei, Ng Bee Hong, Yuen Kah Hay, Lutfi Shuaib Ibrahim, Nesaretnam Kalanithi
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Southeast Asian J Trop Med Public Health. 2010 Jul;41(4):936-42.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and a frequent finding on ultrasound examination. NAFLD is considered as the liver component of metabolic syndrome and is linked to accelerated atherosclerosis and cardiovascular disease. No data from systematic studies regarding the prevalence of NAFLD are available for the Malaysian population. One hundred eighty untreated hypercholesterolemic volunteers underwent blood and ultrasound examinations to evaluate their livers. NAFLD was diagnosed in 102 subjects (56.7%) with similar prevalences between sexes. Of the 102 positive subjects 82 (80.4%) were graded as mild, 17 (16.7%) as moderate and 3 (2.9%) as severe fatty liver cases. Elevated fasting plasma glucose (FPG) levels were found in 13 of 180 subjects (7.2%), while elevated AST and ALT levels were seen in 30 (16.7%) and 22 (12.2%) of the180 subjects, respectively.
非酒精性脂肪性肝病（NAFLD）是全球最常见的肝脏疾病，也是超声检查中常见的发现。NAFLD被认为是代谢综合征的肝脏组成部分，与动脉粥样硬化加速和心血管疾病有关。目前尚无关于马来西亚人群NAFLD患病率的系统研究数据。180名未经治疗的高胆固醇血症志愿者接受了血液和超声检查以评估他们的肝脏。102名受试者（56.7%）被诊断为NAFLD，男女患病率相似。在102名阳性受试者中，82名（80.4%）被评为轻度，17名（16.7%）为中度，3名（2.9%）为重度脂肪肝病例。180名受试者中有13名（7.2%）空腹血糖（FPG）水平升高，而180名受试者中分别有30名（16.7%）和22名（12.2%）的AST和ALT水平升高。
