Health Services Academy, Islamabad, Pakistan.
Department of Medicine, AJK Medical College, Muzaffarabad, Pakistan.
Front Public Health. 2022 Dec 13;10:1008878. doi: 10.3389/fpubh.2022.1008878. eCollection 2022.
An estimated 8 million people die each year from tobacco smoking, with an increasing frequency recently being observed in Southeast Asian countries, which is a preventable risk factor for mortality. NAFLD, fibrosis, advancement of hepatocellular carcinoma, and prognosis for those with severe liver disease are all negatively influenced. NAFLD and cigarette usage seem to be a direct link. Oxidative stress and oncogenic signals have been implicated in cancer development in animal models and human clinical trials. The elevated risk of cardiovascular disease and malignancies in those with steatohepatitis and those who have had liver transplants is exacerbated by smoking. We found that smoking cessation may increase treatment response and fibrosis regression rates, decrease hepatocellular carcinoma incidence, and improve liver transplant outcomes. In the last segment, we'll look at electronic cigarettes, a hot subject in public health right now, as well as additional repercussions of smoking.
每年有大约 800 万人死于烟草使用,最近在东南亚国家中观察到这一趋势的频率不断增加,这是导致死亡的可预防风险因素。非酒精性脂肪性肝病、纤维化、肝细胞癌的进展以及严重肝病患者的预后都受到负面影响。非酒精性脂肪性肝病和吸烟之间似乎存在直接联系。在动物模型和人类临床试验中,氧化应激和致癌信号被认为与癌症的发展有关。在患有脂肪性肝炎和进行过肝移植的患者中,吸烟会加剧心血管疾病和恶性肿瘤的风险。我们发现,戒烟可能会增加治疗反应和纤维化消退的速度,降低肝细胞癌的发生率,并改善肝移植的结果。在最后一部分,我们将探讨电子烟,这是当前公共卫生领域的一个热门话题,以及吸烟的其他影响。