Wong Robert J, Ahmed Aijaz
Robert J Wong, Aijaz Ahmed, Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States.
World J Hepatol. 2014 May 27;6(5):263-73. doi: 10.4254/wjh.v6.i5.263.
Obesity is a global epidemic contributing to an increasing prevalence of obesity-related systemic disorders, including nonalcoholic fatty liver disease. The rising prevalence of nonalcoholic steatohepatitis (NASH) will in the near future lead to end-stage liver disease in a large cohort of patients with NASH-related cirrhosis and NASH is predicted to be a leading indication for liver transplantation in the coming decade. However, the prevalence of obesity and the progression of hepatic histological damage associated with NASH exhibit significant ethnic disparities. Despite a significantly lower body mass index and lower rates of obesity compared to other ethnic groups, Asians continue to demonstrate a significant prevalence of hypertension, diabetes, metabolic syndrome and NASH. Ethnic disparities in central adiposity and visceral fat distribution have been hypothesized to contribute to these ethnic disparities. The current review focuses on the epidemiology of obesity and NASH among Asian populations.
肥胖是一种全球性流行病，导致与肥胖相关的全身性疾病的患病率不断上升，包括非酒精性脂肪性肝病。非酒精性脂肪性肝炎（NASH）患病率的上升在不久的将来将导致大量NASH相关肝硬化患者发展为终末期肝病，预计在未来十年NASH将成为肝移植的主要指征。然而，肥胖的患病率以及与NASH相关的肝脏组织学损伤的进展存在显著的种族差异。尽管与其他种族相比，亚洲人的体重指数显著较低且肥胖率较低，但亚洲人高血压、糖尿病、代谢综合征和NASH的患病率仍然很高。中心性肥胖和内脏脂肪分布的种族差异被认为是导致这些种族差异的原因。本综述重点关注亚洲人群中肥胖和NASH的流行病学。
