对从绵羊和山羊中分离的克罗地亚口疮病毒的系统进化分析。
Phylogenetic analysis of Croatian orf viruses isolated from sheep and goats.
机构信息
Department of Virology, Croatian Veterinary Institute, Savska cesta 143, 10000 Zagreb, Croatia.
出版信息
Virol J. 2010 Nov 12;7:314. doi: 10.1186/1743-422X-7-314.
BACKGROUND
The Orf virus (ORFV) is the prototype of the parapoxvirus genus and it primarily causes contagious ecthyma in goats, sheep, and other ruminants worldwide. In this paper, we described the sequence and phylogenetic analysis of the B2L gene of ORFV from two natural outbreaks: i) in autochthonous Croatian Cres-breed sheep and ii) on small family goat farm.
RESULTS
Sequence and phylogenetic analyses of the ORFV B2L gene showed that the Cro-Cres-12446/09 and Cro-Goat-11727/10 were not clustered together. Cro-Cres-12446/09 shared the highest similarity with ORFV NZ2 from New Zealand, and Ena from Japan; Cro-Goat-11727/10 was closest to the HuB from China and Taiping and Hoping from Taiwan.
CONCLUSION
Distinct ORFV strains are circulating in Croatia. Although ORFV infections are found ubiquitously wherever sheep and goats are farmed in Croatia, this is the first information on genetic relatedness of any Croatian ORFV with other isolates around the world.
背景
口疮病毒（ORFV）是副痘病毒属的原型病毒，它主要引起全世界山羊、绵羊和其他反刍动物的接触性传染性脓疱病。在本文中，我们描述了源自两次自然暴发的 ORFV B2L 基因的序列和系统发育分析：i）在克罗地亚本土的克雷斯品种绵羊中，ii）在小型家庭山羊养殖场中。
结果
ORFV B2L 基因的序列和系统发育分析表明，克-克雷斯-12446/09 株和克-山羊-11727/10 株没有聚集在一起。克-克雷斯-12446/09 株与来自新西兰的 ORFV NZ2 和日本的 Ena 株具有最高的相似性；克-山羊-11727/10 株与中国的 HuB 株以及台湾的 Taiping 和 Hoping 株最为接近。
结论
在克罗地亚存在不同的 ORFV 株系。尽管 ORFV 感染在克罗地亚凡是饲养绵羊和山羊的地方都普遍存在，但这是有关任何克罗地亚 ORFV 株与世界其他分离株遗传相关性的首次信息。
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