Olivero Natalia, Reolon Eduardo, Arbiza Juan, Berois Mabel
Sección Virología, Facultad de Ciencias, UdelaR, Iguá 4225, 11400, Montevideo, Uruguay.
Institut Pasteur de Montevideo, 11400, Montevideo, Uruguay.
Arch Virol. 2018 May;163(5):1285-1291. doi: 10.1007/s00705-018-3717-x. Epub 2018 Jan 24.
Orf virus (ORFV) is the etiological agent of contagious ecthyma, a disease widely spread in the world that occasionally causes zoonotic infections. This work is the first molecular characterization of ORFV in Uruguay, where we analyzed twenty-one sheep samples, eighteen of which were recovered from thirteen ORFV outbreaks that occurred during 2004 to 2011 as well as three strains from a national vaccine. Phylogenetic analysis and the derived amino acid sequences from the B2L gene suggest that the Uruguayan virus do not form a unique cluster, with most of them displaying similarities with worldwide ORFV isolates as well as our vaccine strains.
羊口疮病毒（ORFV）是传染性脓疱性皮炎的病原体，这种疾病在全球广泛传播，偶尔会导致人畜共患感染。这项工作是对乌拉圭境内ORFV的首次分子特征分析，我们分析了21份绵羊样本，其中18份取自2004年至2011年期间发生的13次ORFV疫情，另外3株来自一种国产疫苗。系统发育分析以及从B2L基因推导的氨基酸序列表明，乌拉圭病毒并未形成一个独特的聚类，它们中的大多数与全球范围内的ORFV分离株以及我们的疫苗株具有相似性。
