Department of General Surgery, General Surgery Residency Program, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA.
Surg Clin North Am. 2010 Dec;90(6):1147-60. doi: 10.1016/j.suc.2010.08.009.
Biofilms are a collection of microbes that adhere to surfaces by manufacturing a matrix that shields them from environmental elements. Wound biofilms are difficult to evaluate clinically, and standard culture methods are inadequate for capturing the true bioburden present in the biofilm. New molecular techniques provide the means for rapid detection and evaluation of wound biofilms, and may prove to be useful in the clinical setting. Studies have shown that many commercial topical agents and wound dressings in use are ineffective against the biofilm matrix. At this stage, mechanical debridement appears to be essential in the eradication of a wound biofilm. Topical antimicrobial agents and antibiotics may be effective in the treatment of the wound bed after debridement in the prevention of biofilm reformation.
生物膜是由微生物组成的集合体，它们通过制造基质来附着在表面上，从而使它们免受环境因素的影响。伤口生物膜在临床上难以评估，标准的培养方法不足以捕捉生物膜中存在的真实生物负荷。新的分子技术为快速检测和评估伤口生物膜提供了手段，并且可能在临床环境中证明是有用的。研究表明，许多商业上使用的局部治疗剂和伤口敷料对生物膜基质无效。在现阶段，机械清创似乎是根除伤口生物膜所必需的。在清创后，局部抗菌剂和抗生素可能在预防生物膜再形成方面对伤口床的治疗有效。
