远程控制翻译。

Translation by remote control.

机构信息

Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, C.F. Møllers Allé 3, Building 1130, Aarhus University, 8000 Aarhus, Denmark.

出版信息

Cell. 2010 Nov 12;143(4):501-2. doi: 10.1016/j.cell.2010.10.039.

DOI:10.1016/j.cell.2010.10.039

PMID:21074041

Abstract

Efficient and accurate gene expression requires the coordination of multiple steps along the pathway of mRNA and protein synthesis. Now, Harel-Sharvit et al. (2010) show that transcriptional imprinting of mRNAs with two subunits of RNA polymerase II, Rbp4p and Rpb7p, guides transcripts to the translation apparatus.

摘要

高效且精确的基因表达需要沿着 mRNA 和蛋白质合成途径的多个步骤进行协调。现在，Harel-Sharvit 等人（2010）表明，RNA 聚合酶 II 的两个亚基 Rbp4p 和 Rpb7p 对 mRNA 的转录印迹指导转录本到达翻译装置。