Forman Stuart A
Department of Anesthesia, Critical Care & Pain Medicine, Massachusetts General Hospital, Jackson 4, MGH, 55 Fruit Street, Boston, MA 02114, USA.
Anesthesiol Clin. 2010 Dec;28(4):761-71. doi: 10.1016/j.anclin.2010.08.004.
Over the last several decades, the average age of patients has steadily increased, whereas the use of general anesthesia and deep sedation has grown largely outside the operating room environment. Currently available general anesthetics and delivery models represent limitations in addressing these trends. At the same time, research has tremendously expanded the knowledge of how general anesthetics produce their beneficial effects and also revealed evidence of previously unappreciated general anesthetic toxicities. The goal of this review is to highlight these important developments and describe translational research on new general anesthetics with the potential to improve and reshape clinical care.
在过去几十年中，患者的平均年龄稳步上升，而全身麻醉和深度镇静的使用在很大程度上已扩展至手术室环境之外。目前可用的全身麻醉药和给药模式在应对这些趋势方面存在局限性。与此同时，研究极大地扩展了我们对全身麻醉药如何产生有益作用的认识，也揭示了此前未被认识到的全身麻醉药毒性的证据。本综述的目的是突出这些重要进展，并描述关于新型全身麻醉药的转化研究，这些研究有可能改善和重塑临床护理。
