Meinig School of Biomedical Engineering, Cornell University, Ithaca NY.
Circ Res. 2021 Apr 30;128(9):1344-1370. doi: 10.1161/CIRCRESAHA.121.318011. Epub 2021 Apr 29.
Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy exists outside of prosthetic replacement. The increasing proportion of younger and more active patients mandates alternative therapies. Studies suggest a window of opportunity for biologically based diagnostics and therapeutics to alleviate or delay calcific aortic valve disease progression. Advancement, however, has been hampered by limited understanding of the complex mechanisms driving calcific aortic valve disease initiation and progression towards clinically relevant interventions.
钙化性主动脉瓣疾病在全球范围内的负担显著增加，但除了人工瓣膜置换术之外，尚无其他治疗方法。越来越多的年轻和活跃的患者需要替代治疗。研究表明，有机会利用基于生物学的诊断和治疗方法来减轻或延缓钙化性主动脉瓣疾病的进展。然而，由于对驱动钙化性主动脉瓣疾病发生和向临床相关干预进展的复杂机制的理解有限，进展受到了阻碍。
