Linking Klotho, Nrf2, MAP kinases and aging.
作者信息
Balasubramanian Priya, Longo Valter D
机构信息
Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA.
出版信息
Aging (Albany NY). 2010 Oct;2(10):632-3. doi: 10.18632/aging.100219.
Abstract
摘要
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本文引用的文献
1
The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging.在衰老的Klotho小鼠模型中，ASK1信号体响应内源性氧化应激水平调节p38丝裂原活化蛋白激酶活性。
Aging (Albany NY). 2010 Sep;2(9):597-611. doi: 10.18632/aging.100194.
2
Hepatic response to oxidative injury in long-lived Ames dwarf mice.长寿 Ames 矮小鼠肝脏对氧化损伤的反应。
FASEB J. 2011 Jan;25(1):398-408. doi: 10.1096/fj.10-164376. Epub 2010 Sep 8.
3
Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS).来自长寿艾姆斯侏儒小鼠的真皮成纤维细胞维持其对线粒体产生的活性氧（ROS）的体内抗性。
Aging (Albany NY). 2009 Jul 31;1(9):784-802. doi: 10.18632/aging.100077.
4
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.Nrf2介导热量限制诱导的癌症保护作用，但不介导其延长寿命的作用。
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2325-30. doi: 10.1073/pnas.0712162105.
5
Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice.硫氧还蛋白-ASK1复合物水平调节衰老和长寿的斯内尔侏儒小鼠肝脏中ROS介导的p38丝裂原活化蛋白激酶途径活性。
FASEB J. 2006 Feb;20(2):259-68. doi: 10.1096/fj.05-4376com.
6
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.体细胞线粒体DNA突变会导致衰老表型，而不影响活性氧的产生。
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8. doi: 10.1073/pnas.0508886102. Epub 2005 Dec 6.
7
Regulation of oxidative stress by the anti-aging hormone klotho.抗衰老激素α-klotho对氧化应激的调节作用
J Biol Chem. 2005 Nov 11;280(45):38029-34. doi: 10.1074/jbc.M509039200. Epub 2005 Sep 26.
8
Suppression of aging in mice by the hormone Klotho.激素α-klotho对小鼠衰老的抑制作用。
Science. 2005 Sep 16;309(5742):1829-33. doi: 10.1126/science.1112766. Epub 2005 Aug 25.
9
Aging: a theory based on free radical and radiation chemistry.衰老：一种基于自由基与辐射化学的理论。
J Gerontol. 1956 Jul;11(3):298-300. doi: 10.1093/geronj/11.3.298.
10
The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid.衰老对小鼠肝脏中p38信号通路活性以及对3-硝基丙酸产生的活性氧的反应的影响。
Mech Ageing Dev. 2002 Sep;123(11):1423-35. doi: 10.1016/s0047-6374(02)00084-2.
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