Department of Clinical Sciences, University of Parma, Parma, Italy.
Kidney Int. 2010 Dec;78(11):1063-5. doi: 10.1038/ki.2010.345.
Growing evidence has assigned to oxalate a pivotal role in calcium nephrolithiasis pathophysiology. A better understanding of the mechanisms behind intestinal absorption and renal excretion has led to the identification of new treatments. Among these, diet and probiotics appear promising in terms of safety and rationale. However, the discrepancy between in vitro and in vivo results requires further studies to identify the right patient target, the correct dosage, and the real modification of natural and clinical history of nephrolithiasis.
越来越多的证据表明，草酸盐在钙肾结石病理生理学中起着关键作用。对肠道吸收和肾脏排泄背后机制的深入了解，促使人们发现了新的治疗方法。在这些方法中，饮食和益生菌在安全性和合理性方面似乎很有前景。然而，体外和体内结果之间的差异需要进一步的研究，以确定合适的患者目标、正确的剂量，并真正改变肾结石的自然和临床病史。
