Schicht M, Posa A, Paulsen F, Bräuer L
Institut für Anatomie und Zellbiologie, Martin-Luther-Universität Halle-Wittenberg, Halle.
Klin Monbl Augenheilkd. 2010 Nov;227(11):864-70. doi: 10.1055/s-0029-1245609. Epub 2010 Nov 12.
The amphiphilic surfactant proteins B (SP-B) and C (SP-C) are tightly bound to phospholipids. These proteins play important roles in maintaining the surface tension-lowering properties of pulmonary surfactant. Surfactant protein A (SP-A) and D (SP-D) are hydrophilic and are thought to have a role in recycling surfactant and, especially, in improving host defense in the lung. Moreover, SP-A supports the hydrophobic surfactant proteins B and during surfactant subtype assembly and inhibits the secretion of lamellar bodies into the alveolar space. During recent years surfactant proteins have also been detected at locations outside the lung such as the lacrimal apparatus. In this review, the latest information regarding SP function and regulation in the human lacrimal system, the tear film and the ocular surface is summarised with regard to dry eye, rheological and antimicrobial properties of the tear film, tear outflow, certain disease states and possible therapeutic perspectives.
两亲性表面活性蛋白B（SP-B）和C（SP-C）与磷脂紧密结合。这些蛋白质在维持肺表面活性剂降低表面张力的特性方面发挥着重要作用。表面活性蛋白A（SP-A）和D（SP-D）是亲水性的，被认为在表面活性剂的循环利用中发挥作用，特别是在改善肺部的宿主防御方面。此外，SP-A在表面活性剂亚型组装过程中支持疏水性表面活性蛋白B，并抑制板层小体分泌到肺泡腔中。近年来，在肺外的部位如泪器中也检测到了表面活性蛋白。在这篇综述中，总结了关于人泪液系统、泪膜和眼表中SP功能和调节的最新信息，涉及干眼、泪膜的流变学和抗菌特性、泪液流出、某些疾病状态以及可能的治疗前景。
