Department of Histology and Embryology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.
Phytother Res. 2011 Jun;25(6):796-802. doi: 10.1002/ptr.3334. Epub 2010 Nov 12.
This study evaluated the possible effects of flaxseed oil on renal damage associated with hyperlipidaemic rats. Wistar albino male rats were divided into three groups. Group I was fed with a pellet chow. Group II was fed with a high cholesterol diet (HCD) consisting of 5% cholesterol and 0.35% cholic acid added to the pellet chow. Group III was fed with the same HCD, but were orally treated with a dose of 15 mg/kg body wt/day flaxseed oil. Flaxseed oil treatment started 1 week before and continued throughout the 22 weeks of the HCD. At the end of the experiment, renal tissue and blood samples were collected. The biochemical and histopathological findings confirmed renal damage in hypercholesterolaemia conditions. Flaxseed oil reduced the hypercholesterolaemia-induced increase in the serum levels of total cholesterol, LDL and urea. Oil red O stain revealed that lowered serum lipid was accompanied by a decreased deposition of neutral lipid. Flaxseed oil effectively reversed these abnormalities, verifying the protective effects of flaxseed oil in ameliorating renal injuries associated with hypercholesterolaemia.
本研究评估了亚麻籽油对高脂血症大鼠相关肾损伤的可能影响。Wistar 白化雄性大鼠被分为三组。第 I 组喂食颗粒状饲料。第 II 组喂食高胆固醇饮食（HCD），即在颗粒状饲料中添加 5%胆固醇和 0.35%胆酸。第 III 组喂食相同的 HCD，但每天口服 15mg/kg 体重的亚麻籽油。亚麻籽油治疗在 HCD 的前 1 周开始，并持续进行 22 周。实验结束时，收集肾组织和血液样本。生化和组织病理学发现证实了高胆固醇血症条件下的肾脏损伤。亚麻籽油降低了高胆固醇血症引起的血清总胆固醇、LDL 和尿素水平升高。油红 O 染色显示，降低的血清脂质伴随着中性脂质沉积的减少。亚麻籽油有效地逆转了这些异常，验证了亚麻籽油在改善与高胆固醇血症相关的肾脏损伤方面的保护作用。
