Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA.
J Am Chem Soc. 2010 Dec 8;132(48):17108-10. doi: 10.1021/ja108949w. Epub 2010 Nov 15.
The stereospecific cross-coupling of enantioenriched nonbenzylic secondary alkyl boron compounds has been achieved. The high selectivity toward product formation over an undesired β-H elimination pathway is achieved via an intramolecular coordination of an ancillary carbonyl to the metal center in the diorganopalladium intermediate.
对映富集的非苄基仲烷基硼化合物的立体专一交叉偶联已经实现。通过二芳基钯中间体中辅助羰基与金属中心的分子内配位,实现了产物形成的高选择性,而不是不希望的β-H 消除途径。