Roy and Diana A. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
Org Lett. 2010 Oct 1;12(19):4384-7. doi: 10.1021/ol101865e.
Enantiomerically enriched potassium β-trifluoroboratoamides were synthesized as air-stable solids in greater than 95:5 dr using pseudoephedrine as the chiral auxiliary. With these chiral nucleophiles, Suzuki-Miyaura cross-coupling reactions were carried out with various aryl- and hetaryl chlorides in good to excellent yields. Moreover, the diastereoselectivities were preserved throughout the Suzuki-Miyaura cross-coupling reactions.
外消旋体富集的钾 β-三氟硼酰胺作为空气稳定的固体，以伪麻黄碱作为手性助剂，以大于 95:5 dr 的比例合成。使用这些手性亲核试剂，与各种芳基和杂芳基氯化物进行 Suzuki-Miyaura 交叉偶联反应，产率良好到优秀。此外，在整个 Suzuki-Miyaura 交叉偶联反应中，非对映选择性得到了保持。
