Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Trop Med Int Health. 2011 Feb;16(2):145-51. doi: 10.1111/j.1365-3156.2010.02686.x. Epub 2010 Nov 16.
To assess the susceptibility of community-acquired pathogens in neonatal sepsis to commonly prescribed antibiotics in sub-Saharan Africa and Asia since 2002.
Literature review in PubMed and Embase. Susceptibility was estimated for pathogens individually and stratified by region. Isolates were also classified into Gram positive and Gram negative pathogens to estimate their pooled susceptibility.
Only nine studies met the inclusion criteria. The available data indicated poor susceptibility to almost all commonly used antibiotics in pathogens such as Staphylococcus aureus and Klebsiella spp. Only Streptococcus pneumoniae exhibited good susceptibility to all drugs other than cotrimoxazole. The extreme scarcity of data prevents drawing any firm conclusions beyond the urgent need for more studies to identify the best treatments for neonatal sepsis in the developing world.
评估自 2002 年以来撒哈拉以南非洲和亚洲社区获得性新生儿败血症病原体对常用抗生素的敏感性。
在 PubMed 和 Embase 中进行文献回顾。单独评估了病原体的敏感性，并按地区进行分层。还将分离株分为革兰氏阳性和革兰氏阴性病原体，以估计其 pooled 敏感性。
只有九项研究符合纳入标准。现有数据表明，金黄色葡萄球菌和克雷伯氏菌等病原体对几乎所有常用抗生素的敏感性都很差。只有肺炎链球菌对除复方新诺明以外的所有药物均表现出良好的敏感性。数据的极度缺乏使得除了迫切需要进行更多研究以确定发展中国家新生儿败血症的最佳治疗方法之外，无法得出任何确凿的结论。
