Division of Neonatology, Department of Pediatrics, Boston University School of Medicine, 771 Albany Street - Dowling 4111, Boston, MA 02118, USA.
Clin Perinatol. 2010 Dec;37(4):907-27, xi. doi: 10.1016/j.clp.2010.08.006.
Antiretrovirals may be used in pregnant women infected with the HIV and their newborns both for treatment of maternal HIV disease and for prevention of mother-to-child transmission of HIV. More than 25 antiretroviral agents in 5 classes have been approved, with new drugs and classes in development. This article reviews current knowledge of the pharmacology of these drugs during pregnancy and in the newborn period, highlighting those pharmacologic issues critical to the safe and effective use of antiretrovirals in these populations.
抗逆转录病毒药物可用于治疗感染 HIV 的孕妇及其新生儿，以治疗母体 HIV 疾病并预防 HIV 母婴传播。目前已有超过 25 种 5 类抗逆转录病毒药物获得批准，还有新的药物和类别正在研发中。本文综述了这些药物在妊娠期间和新生儿期的药理学知识，重点介绍了对这些人群安全有效使用抗逆转录病毒药物至关重要的药理学问题。
