University of Toronto Lupus Clinic and Centre for Prognosis Studies in the Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.
J Rheumatol. 2011 Jan;38(1):60-3. doi: 10.3899/jrheum.100575. Epub 2010 Nov 15.
adjusted mean Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; AMS) measures lupus disease activity over time. Our aim was to determine optimal visit frequency for calculating AMS.
patients followed monthly for 12 consecutive visits were included. AMS was calculated using all of the SLEDAI 2000 (AMS(GOLD) using all 12 visits), only quarterly visits (AMS(3), using visits 3 months apart), semiannual visits (AMS(6), using first, middle, and last visits only), and annual visits (AMS(12), using only the first and last visits). Comparisons of AMS(3), AMS(6), and AMS(12) with AMS(GOLD) are made using descriptive statistics.
seventy-eight patients were included (92% women, mean age at SLE diagnosis 30.1 yrs and at study start 46.2 yrs). The mean (SD) AMS(GOLD) for the entire year was 2.05 (1.66), for AMS(3) 1.99 (1.65), for AMS(6) 2.12 (1.87), and for AMS(12) 2.08 (1.83). Mean (SD) of the absolute differences with AMS(GOLD): for AMS(3) 0.29 (0.33), for AMS(6) 0.45 (0.59), and for AMS(12) 0.61 (0.58). Differences that were < 0.5 were considered minimal while those ≥ 1 were deemed important. Comparing AMS(GOLD) to AMS(3), 82% of the differences were minimal and 3% were important. When comparing to AMS(6), 68% were minimal and 10% were important, while comparing to AMS(12), 50% were minimal and 21% were important.
usual clinic visits occurring quarterly offer a good estimation of disease activity over a 1-year period and are preferred over semiannual and annual visits.
调整后的系统性红斑狼疮疾病活动指数（SLEDAI；AMS）衡量随时间推移的狼疮疾病活动。我们的目的是确定计算 AMS 的最佳就诊频率。
纳入连续 12 次每月就诊的患者。使用所有 2000 年 SLEDAI（使用所有 12 次就诊的 AMS(GOLD)）、仅每季度就诊（AMS(3)，每 3 个月就诊一次）、每半年就诊（AMS(6)，仅使用第一次、中间和最后一次就诊）和每年就诊（AMS(12)，仅使用第一次和最后一次就诊）计算 AMS。使用描述性统计比较 AMS(3)、AMS(6)和 AMS(12)与 AMS(GOLD)。
共纳入 78 例患者（92%为女性，SLE 诊断时的平均年龄为 30.1 岁，研究开始时的平均年龄为 46.2 岁）。全年 AMS(GOLD)的平均值（SD）为 2.05（1.66），AMS(3)为 1.99（1.65），AMS(6)为 2.12（1.87），AMS(12)为 2.08（1.83）。与 AMS(GOLD)的绝对差异平均值（SD）：AMS(3)为 0.29（0.33），AMS(6)为 0.45（0.59），AMS(12)为 0.61（0.58）。差异<0.5 被认为是微小的，而≥1 则被认为是重要的。与 AMS(GOLD)相比，82%的差异较小，3%的差异较大。与 AMS(6)相比，68%的差异较小，10%的差异较大，而与 AMS(12)相比，50%的差异较小，21%的差异较大。
每季度进行的常规就诊可很好地估计 1 年内的疾病活动情况，优于每半年和每年就诊。
